Related Experiment Video
Updated: Aug 15, 2026

Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
Published on: August 16, 2010
Disposition of phencyclidine after intramuscular administration
Abstract:
The disposition of radioactive phencyclidine (PCP) in various rat tissues, after single or repeated intramuscular injections for 23 days, have been investigated. Peak levels of radioactivity appeared 45-90 min after a single administration. The pancreas, salivary glands and mesenteric fat contained 4 to 6-fold higher radioactivity than brain, muscles, tendons, and bones. After repeated 3H-PCP injections, radioactivity levels showed a similar pattern as to that of the peak levels after a single administration, but at notably higher values. On the other hand, the percentage of depletion, within 48 h after the final injection, was the highest in the pancreas, salivary glands and mesenteric fat. It is possible that despite the low retention capacity of PCP radioactivity per unit weight of muscle, tendon and bone, they may be considered important reservoirs for either PCP, or its metabolites or both because of their large relative mass in the body.
Related Concept Videos
Routes of Drug Administration: Parenteral
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
Compartment Models: Two-Compartment Model
Indirect-Acting Cholinergic Agonists: Pharmacokinetics
Reversible agents containing quaternary amines, such as neostigmine and edrophonium, are not easily absorbed orally because they are...
Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacokinetics
Instead, they are transported by the blood to different tissues. Muscles with a greater blood supply (arteries) and blood flow receive more...
Depolarizing Blockers: Pharmocokinetics
Drug Accumulation During Multiple Dosing: Repetitive IV Injections

