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Related Experiment Videos

Warfarin and the grey squirrel.

C M Chambers, P L Chambers

    Archives of Toxicology. Supplement. = Archiv Fur Toxikologie. Supplement
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Warfarin effectively elevates prothrombin times in grey squirrels, even at low doses, indicating anticoagulant activity. This study assessed warfarin

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    Area of Science:

    • Veterinary Toxicology
    • Wildlife Management
    • Pharmacology

    Background:

    • Warfarin is used for grey squirrel control in Great Britain.
    • Its efficacy and toxicity in Ireland require assessment due to low native mammal populations.
    • Data on warfarin's toxicity to squirrels is limited.

    Purpose of the Study:

    • To determine the effectiveness of warfarin in controlling grey squirrels (Sciurus carolinensis).
    • To identify the least effective dose of warfarin for grey squirrel treatment.
    • To assess potential toxic effects on native Irish mammals.

    Main Methods:

    • Grey squirrels were administered warfarin at four concentrations (6.0, 1.25, 0.5, 0.01 mg/kg) via stomach tube.
    • Prothrombin times (PT) were monitored to assess warfarin's anticoagulant action.

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  • Statistical analysis was performed on PT data compared to control values.

    • Main Results:

    • Elevated prothrombin times were observed in squirrels treated with warfarin, even at the lowest dose (0.01 mg/kg) by day 7.
    • The increase in PT was statistically significant (p=0.05), exceeding 30 seconds.
    • One squirrel at 0.5 mg/kg showed a temporary PT increase, returning to normal within 22 days despite continued dosing.

    Conclusions:

    • Warfarin demonstrates anticoagulant effects in grey squirrels at tested concentrations.
    • The study provides crucial data for assessing warfarin's suitability for grey squirrel management in Ireland.
    • Further research may be needed to fully understand long-term effects and species-specific toxicity.