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Related Experiment Videos

Models to predict cannabinoid-induced disturbances.

H Edery

    Archives of Toxicology. Supplement. = Archiv Fur Toxikologie. Supplement
    |January 1, 1983
    PubMed
    Summary

    The monkey model effectively mimics human responses to cannabinoids, aiding in the development of non-psychoactive cannabinoid-based drugs. This model shows promise for evaluating drug safety and efficacy.

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    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement·1983

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Drug Development

    Background:

    • Developing cannabinoid-based drugs requires accurate models to assess psychoactivity.
    • Existing animal models for cannabinoid research need to be sensitive, specific, and simple.

    Purpose of the Study:

    • To review animal models for evaluating cannabinoid psychoactivity.
    • To identify a suitable model for developing non-psychoactive cannabinoid drugs.

    Main Methods:

    • Review of existing literature on animal models for cannabinoid psychoactivity.
    • Behavioral and physiological assessments in rhesus monkeys and baboons.
    • Evaluation of synthetic amino-cannabinoids in baboons.

    Main Results:

    • The monkey model closely replicates human behavioral responses to cannabinoids, including tolerance and withdrawal.
    • Rhesus monkeys exhibit brain alterations similar to humans upon cannabinoid exposure.
    • Newly synthesized amino-cannabinoids showed minimal psychoactivity, with trans-analogs inducing unique scratching and yawning behaviors.

    Conclusions:

    • The monkey model is a valuable tool for cannabinoid research, particularly for assessing psychoactivity and guiding drug development.
    • Further investigation into the novel effects of trans-amino-cannabinoids is warranted.

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