Related Experiment Videos
Immunoglobulin producing cells in human periapical granulomas
The British Journal of Oral Surgery
|September 1, 1983
Summary
This study examined plasma cell distribution in periapical granulomas, finding IgG cells predominated. IgE plasma cells were also present, suggesting a role for hypersensitivity reactions in pathogenesis.
Area of Science:
- Immunology
- Oral Pathology
- Cell Biology
Background:
- Periapical granulomas are inflammatory responses to pulpal necrosis.
- The role of specific immunoglobulin classes in their pathogenesis is not fully understood.
Purpose of the Study:
- To investigate the class distribution of plasma cells in periapical granuloma lesions.
- To explore the potential role of different immunoglobulin classes in the pathogenesis of periapical granuloma.
Main Methods:
- Ten cases of periapical granuloma were analyzed.
- Immunohistochemistry using the unlabelled antibody peroxidase-antiperoxidase complex method was employed.
- Staining for IgG, IgA, IgM, IgD, and IgE plasma cells was performed.
Main Results:
- Immunoglobulin G (IgG) containing plasma cells were predominant in all lesions.
- The distribution of plasma cells was IgG (81.9%), IgA (11.4%), IgM (5.4%), IgE (1.1%), and IgD (0.2%).
- IgE plasma cells and non-lymphoid cells with IgE staining were observed in all specimens.
Conclusions:
- IgG plasma cells are the major immunoglobulin class in periapical granulomas.
- The presence of IgE plasma cells suggests a potential role for immediate hypersensitivity reactions in lesion pathogenesis.
- Immune complex deposition and IgE-mediated reactions may contribute to tissue damage in periapical granulomas.