Accelerated periodontal disease in a patient with essential mixed cryoglobulinemia

A 32-year-old woman diagnosed as having Type III essential mixed cryoglobulinemia presented with a history of gingival swelling and hemorrhage. Further clinical findings, in addition to sequential radiographs, revealed the presence of an unusual case of rapidly progressive periodontitis. An association between the presence of cryoglobulinemia and the periodontitis is implicated.