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[Hepatic involvement in pediatric neoplasms].

B De Bernardi, A Garaventa, R Giacchino

    La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics
    |March 1, 1983
    PubMed
    Summary

    Pediatric liver toxicity from cancer and its treatments is complex, involving tumors and chemotherapy. Acute hepatitis in leukemia patients may even transiently improve their cancer.

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    Pediatric hematology and oncology·2016

    Area of Science:

    • Hepatology
    • Pediatric Oncology
    • Toxicology

    Context:

    • The liver is highly susceptible to toxic effects from neoplastic diseases and their treatments in children.
    • Liver toxicity in pediatric cancers presents numerous complex and often difficult-to-explain phenomena.
    • Understanding these toxicities is crucial for managing pediatric cancer patients.

    Purpose:

    • To categorize and describe the diverse forms of liver toxicity in pediatric neoplasias.
    • To investigate the etiopathogenetic mechanisms of liver involvement in various solid tumors and leukemia.
    • To explore the relationship between acute hepatitis and leukemia, including potential therapeutic effects.

    Summary:

    • Liver toxicity in pediatric cancers encompasses primary liver tumors, extrahepatic tumor infiltration, and non-neoplastic causes.
    • Specific toxicity patterns are observed during different phases of acute lymphoblastic leukemia treatment, including induction, consolidation, and maintenance (Methotrexate and 6-mercaptopurine).
    • Acute hepatitis in leukemia patients can paradoxically lead to transient disease remission.

    Impact:

    • Provides a framework for understanding and diagnosing liver toxicity in pediatric cancer.
    • Highlights the need for careful monitoring during chemotherapy, especially with Methotrexate and 6-mercaptopurine.
    • Suggests a potential, albeit transient, antileukemic role for acute liver infections.

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