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Generation of RNA/DNA Hybrids in Genomic DNA by Transformation using RNA-containing Oligonucleotides
16:42

Generation of RNA/DNA Hybrids in Genomic DNA by Transformation using RNA-containing Oligonucleotides

Published on: November 24, 2010

Correction of a genetically caused enzyme defect by somatic cell hybridization

C F Cori, S Gluecksohn-Waelsch, P A Shaw

    Proceedings of the National Academy of Sciences of the United States of America
    |November 1, 1983
    PubMed
    Summary

    Mouse chromosome 7 deletions disrupt liver-specific traits like glucose-6-phosphatase (Glc-6-Pase) activity. Hybridization experiments reveal the Glc-6-Pase structural gene is not deleted, but regulatory genes on chromosome 7 are likely responsible for expression failure.

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