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Macromolecular surface films at a solid/liquid interface.

A Silberberg

    Thrombosis Research. Supplement
    |January 1, 1983
    PubMed
    Summary
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    Macromolecules form a single layer on surfaces when soluble. Multilayer formation, like endoendothelial fibrin, requires altered macromolecule reactivity, influencing fluid dynamics.

    Area of Science:

    • Biophysics
    • Materials Science
    • Fluid Dynamics

    Background:

    • Macromolecules typically form a single adsorbed layer on solid/liquid interfaces due to limited intermolecular interactions in solution.
    • Multilayer formation requires altered macromolecule segment reactivity for adhesion between surface-bound and soluble molecules.

    Purpose of the Study:

    • To explore the conditions necessary for multilayer adsorption of macromolecules.
    • To investigate the potential for multilayer formation, specifically an endoendothelial fibrin layer.
    • To understand the influence of surface-bound layers on fluid flow.

    Main Methods:

    • Theoretical analysis of macromolecule adsorption principles.
    • Consideration of altered reactivity for multilayer formation.

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  • Conceptualization of gel layer effects on fluid dynamics.

    • Main Results:

    • Soluble macromolecules generally do not form multilayers due to weak solution-phase interactions.
    • Multilayer formation is plausible if surface-bound macromolecule segments exhibit altered reactivity.
    • A weakly elastic gel layer significantly impedes fluid flow near the interface.

    Conclusions:

    • The formation of multilayered macromolecule structures, such as endoendothelial fibrin, is possible under specific conditions of altered reactivity.
    • Surface-adsorbed macromolecule layers, particularly gels, can drastically alter local fluid dynamics, slowing or stopping flow.
    • These principles support proposed mechanisms for the buildup and function of endoendothelial fibrin layers.