[Effect of adepren on the rate of cerebral noradrenaline metabolism]

The authors examined the influence of the original Bulgarian antidepressant adepren on the metabolic rate of noradrenaline in the brain of rats. For this purpose they used an isotopic method for incorporation of C14 tyrosine. It was established that adepren lowered the metabolic rate of noradrenaline. The authors explained these changes by the elevated level of brain noradrenaline, found by them, which level inhibited the rate its synthesis by feed back mechanism.