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Chronic open angle glaucoma treated with Timolol. A four year study.

G M Maclure

    Transactions of the Ophthalmological Societies of the United Kingdom
    |January 1, 1983
    PubMed
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    See all related articles

    Topical Timolol effectively lowers intraocular pressure in new chronic open-angle glaucoma patients. This study found Timolol controlled glaucoma in 69.7% of patients, with minimal side effects.

    Area of Science:

    • Ophthalmology
    • Pharmacology

    Background:

    • Topical Timolol is frequently used for chronic open-angle glaucoma.
    • Previous studies often involved patients switching medications after a wash-out period.

    Purpose of the Study:

    • To evaluate the ocular hypotensive effect of topical Timolol in new patients with chronic open-angle glaucoma.
    • To assess the long-term efficacy and safety of Timolol over 4.5 years.

    Main Methods:

    • Prospective study of 82 new chronic open-angle glaucoma patients.
    • Monitored intraocular pressure, visual acuity, visual field, pupil size, pulse rate, blood pressure, and corneal sensitivity.
    • Corneal sensitivity assessed using the Cochet and Bonnet method in a subset of patients.

    Main Results:

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    • Timolol controlled intraocular pressure in 69.7% of the 66 patients who completed the study.
    • Minimal effects observed on blood pressure and pulse rate; no significant impact on pupil diameter, Schirmer's test, or corneal sensitivity.
    • Slight tachyphylaxis was noted in some patients.

    Conclusions:

    • Topical Timolol is an effective and generally well-tolerated treatment for new cases of chronic open-angle glaucoma.
    • Long-term use demonstrates sustained efficacy with a favorable safety profile.