Studies on plasma fibrinogen level in pre-eclampsia and eclampsia.

Area of Science:

• Obstetrics and Gynecology
• Hematology
• Perinatology

Background:

• Preeclampsia and eclampsia are severe hypertensive disorders of pregnancy.
• Plasma fibrinogen is a key coagulation factor that may be altered in pregnancy complications.
• Understanding fibrinogen changes is crucial for managing pregnancy-related hypertensive conditions.

Purpose of the Study:

• To investigate and compare plasma fibrinogen levels in pregnant women with pre-eclampsia, eclampsia, and essential hypertension against normal pregnancies.
• To assess the diagnostic or prognostic value of fibrinogen levels in these conditions.

Main Methods:

• Maternal plasma fibrinogen levels were measured in three groups: 30 pre-eclampsia cases, 60 eclampsia cases, and 35 normal third-trimester pregnancies.
• A comparative analysis was performed between these groups and a group with essential hypertension.

Main Results:

• Plasma fibrinogen levels were elevated by approximately 70% in pre-eclampsia and 145% in eclampsia compared to normal pregnancy.
• In contrast, fibrinogen levels in essential hypertension remained comparable to those in normal pregnancy.

Conclusions:

• Elevated plasma fibrinogen is a significant finding in both pre-eclampsia and eclampsia.
• Fibrinogen levels do not appear to be significantly altered in essential hypertension during pregnancy.
• These findings highlight the potential role of fibrinogen as a biomarker in hypertensive disorders of pregnancy.