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Related Experiment Videos

ALL masquerading as AUL.

M F Greaves, R Bell, J Amess

    Leukemia Research
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Immunological markers help classify acute undifferentiated leukaemia (AUL). Most AUL cases show lymphoid or myeloid lineage, suggesting tailored therapy based on cell type can improve outcomes.

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    Area of Science:

    • Hematology
    • Immunology
    • Oncology

    Background:

    • Acute leukaemia classification is crucial for treatment selection.
    • A significant number of adult acute leukaemias remain unclassified (acute undifferentiated leukaemia - AUL).
    • Immunological markers offer potential for precise leukaemia phenotyping.

    Purpose of the Study:

    • To investigate the immunophenotype of acute undifferentiated leukaemia (AUL) cases.
    • To determine the lineage affiliation of AUL cells using immunological markers.
    • To assess the potential impact of immunophenotyping on AUL treatment strategies.

    Main Methods:

    • Analysis of 597 adult acute leukaemia cases diagnosed between 1973 and 1982.
    • Investigation of 21 AUL cases using a panel of immunological markers.

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  • Retrospective analysis using frozen cell suspensions for immunophenotyping.

    • Main Results:

    • 18 out of 21 AUL cases exhibited a predominantly lymphoid phenotype.
    • Specific lymphoid subtypes identified included common ALL, null-ALL, early thymic, and B lymphoblast phenotypes.
    • One case showed myeloid lineage, and two cases were unreactive with tested markers.

    Conclusions:

    • The majority of AUL cases demonstrate lymphoid or myeloid lineage affiliation.
    • Immunophenotyping can refine the classification of acute leukaemias.
    • Therapeutic strategies for AUL may be optimized by identifying the leukaemic cell type.