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Related Experiment Videos

Enzyme activity in Tourette's syndrome.

A K Shapiro, M Baron, E Shapiro

    Archives of Neurology
    |March 1, 1984
    PubMed
    Summary

    Tourette's syndrome (TS) patients showed higher platelet monoamine oxidase (MAO) and plasma amine oxidase (PAO) activity compared to controls. Enzyme levels were not linked to illness severity, family history, or ethnic background.

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    Area of Science:

    • Neurobiology
    • Biochemistry
    • Genetics

    Background:

    • Tourette's syndrome (TS) is a neurological disorder.
    • Enzyme activity in patients with TS is not fully understood.
    • Monoamine oxidase (MAO) and other enzymes are implicated in neurotransmitter regulation.

    Purpose of the Study:

    • To investigate enzyme activity differences in drug-free TS patients compared to controls.
    • To explore correlations between enzyme activity and clinical/demographic factors in TS.

    Main Methods:

    • Measured activity of MAO, PAO, catechol-o-methyltransferase, and dopamine-beta-hydroxylase.
    • Compared enzyme levels in 24 TS patients and 24 matched controls.
    • Analyzed correlations with age, sex, onset, severity, family history, and ethnicity.

    Main Results:

    • Significantly elevated MAO and PAO activity found in TS patients versus controls.
    • No significant correlations observed between enzyme activity and age, sex, illness severity, or family history.
    • Enzyme activity did not differ based on ethnic background or pedigree loading.

    Conclusions:

    • Elevated MAO and PAO activity may be a biochemical marker in Tourette's syndrome.
    • These enzyme differences are independent of major clinical and demographic variables.
    • Findings do not support a specific biochemical profile for TS based on ethnicity or family history.

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