Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complex visual hallucinations and cyclosporine.

R B Noll, R Kulkarni

    Archives of Neurology
    |March 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Cyclosporine treatment for graft-v-host disease in acute lymphoblastic leukemia patients can cause vision problems and hallucinations. Reducing or stopping cyclosporine resolved these visual disturbances, offering relief.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Clinical features and presentation of cervicofacial infection: a Maxillofacial Trainee Research Collaborative (MTReC) study.

    The British journal of oral & maxillofacial surgery·2021
    Same author

    Delays and barriers to early treatment initiation for childhood tuberculosis in India.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2019
    Same author

    Volatile organic compound measurements point to fog-induced biomass burning feedback to air quality in the megacity of Delhi.

    The Science of the total environment·2019
    Same author

    Systematic review of the role of corticosteroids in cervicofacial infections.

    The British journal of oral & maxillofacial surgery·2019
    Same author

    A comparison of 24 chemicals in the six-well bacterial reverse mutation assay to the standard 100-mm Petri plate bacterial reverse mutation assay in two laboratories.

    Regulatory toxicology and pharmacology : RTP·2018
    Same author

    Women with bleeding disorders.

    Haemophilia : the official journal of the World Federation of Hemophilia·2018

    Area of Science:

    • Ophthalmology
    • Hematology
    • Pharmacology

    Background:

    • Acute lymphoblastic leukemia (ALL) survivors undergoing bone marrow transplantation (BMT) often require immunosuppression to prevent graft-v-host disease (GVHD).
    • Common GVHD prophylaxis includes medications like prednisone and cyclosporine.
    • Visual disturbances are a potential, though less commonly reported, side effect of immunosuppressive therapy.

    Observation:

    • A patient with ALL post-BMT developed sudden vision loss and complex visual hallucinations.
    • These symptoms emerged during treatment with prednisone and cyclosporine for GVHD.
    • The patient experienced significant psychological distress due to the hallucinations.

    Findings:

    • A direct correlation was observed between cyclosporine dosage and the severity of visual symptoms.

    Related Experiment Videos

  • Reduction and eventual cessation of cyclosporine treatment led to spontaneous resolution of both visual acuity loss and hallucinations.
  • This suggests a potential causal link between cyclosporine and the observed visual phenomena.

    • Implications:

    • Cyclosporine-induced visual disturbances should be considered in the differential diagnosis for patients with ALL undergoing BMT.
    • Prompt ophthalmological evaluation and medication review are crucial for managing such cases.
    • Understanding these side effects can improve patient quality of life and psychological well-being during cancer treatment.