The expression of the myc proto-oncogene in a dimethylsulfoxide resistant HL-60 cell line

A cell line partially resistant to dimethylsulfoxide (DMSO) was derived from the HL-60 cell line. Cycloleucine, theophylline, sodium butyrate and elevated levels of DMSO were found to induce myeloid differentiation in this cell line while TPA induced monocytic differentiation. The levels of myc RNA and the genomic structure of the c-myc proto-oncogene were found to be the same in HL-60 and the resistant cell line. Differentiation of the DMSO resistant line was accompanied by a reduction in myc RNA levels.