[Effect of phenobarbital on sulfanilamide acetylation]

By using the "turned inside out bag" technique and brough tests with homogenates it was found that sulfanilamide is susceptible to acetylation in a larger measure than sulfocarbamide and sulfacylum natrium. In tests with isolated lengths of the small intestine phenobarbital (in doses of 25 mg/kg for 5 days) weakened acetylation of sulfanilamide and sulfocarbamide and did not change acetylation of sulfacylum natrium. Acetylation of all these three sulfanilamides in homogenates of the liver, blood and the small intestine mucosa did not change under the effect of phenobarbital.