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Distribution of haematological, serum and urine values in a general population of middle-aged men. The Reykjavik
Insights
This cardiovascular health survey established reference ranges for key biomarkers in middle-aged men. Results showed no significant seasonal variation in these health indicators.
Area of Science:
- Clinical Chemistry
- Cardiovascular Health
- Biomarker Analysis
Background:
- Establishing normative biomarker ranges is crucial for cardiovascular health assessment.
- Previous studies have not comprehensively evaluated seasonal influences on these specific biomarkers in this demographic.
Purpose of the Study:
- To determine reference ranges for various blood and urine biomarkers in middle-aged men.
- To investigate potential seasonal variations in these biomarker levels.
Main Methods:
- Prospective survey of 2955 males aged 34-61 years over 12 months.
- Collection of fasting blood and urine samples for analysis of s-alkaline phosphatase, s-bilirubin, s-creatinine, s-uric acid, haemoglobin, haematocrit, MCHC, ESR, and urine specific gravity.
- Standardized appointment scheduling to control for time-of-day, weekday, and time-of-year effects.
Main Results:
- Approximate 5% and 95% centiles were established for all measured biomarkers.
- No evidence of seasonal variation was observed in the biomarker results.
Conclusions:
- The study provides valuable reference data for key biochemical and hematological parameters in middle-aged men.
- The findings suggest that seasonal factors do not significantly impact these specific health indicators within this population.
Abstract:
In the first stage of a prospective cardiovascular health survey, 2955 males aged 34-61 years were invited for examination during a 12-month period. The response was 75%. Appointments were arranged in such a way that all age groups would be equivalent with respect to time of day, weekday and time of year on which appointments were given. In fasting blood and urine samples the following quantities were estimated: s-alkaline phosphatase (AP), s-bilirubin (Bil), s-creatinine (Cre), s-uric acid (UA), haemoglobin (Hb), haematocrit (Hct), mean cell haemoglobin content (MCHC), erythrocyte sedimentation rate (ESR) and urine specific gravity (USG). The approximate 5% and 95% centiles were as follows: (table; see text) No indication of seasonal variation was found in these results.