[Association of verruciform acrokeratosis with congenital poikiloderma as a dermatologic entity]

An 18-year-old young man, presents multiple areas of poikilodermia since 1 year of age, and papules like flat warts essentially on the back of his hands and feet, since 10 years of age. The examination of 16 of his closest relatives led us to discover 1 case of poikilodermia and acrokeratosis verruciformis, 1 case of poikilodermia and 3 cases of acrokeratosis veruciformis. Observations on the association of poikilodermia and acrokeratosis verruciformis have already been reported in the literature as well as comparable morphological fact, but without family lesions and without histological examinations. Thus, rare patients are presenting both congenital pikilodermia and acrokeratosis verruciformis. In the families of 3 of these patients, some members are similarly afficted, whereas others present independently either poikilodermia or acrokeratosis. In several reports in the literature and in our cases, the histological picture of verruciform papules was the same as Hopf's acrokeratosis verruciformis. These particularities led us to consider the association of Hof's and Thomson's diseases as an entity.