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Related Experiment Videos

Relative aversion thresholds for shock in infant mice.

Z M Nagy, J M Murphy, D Ray

    Developmental Psychobiology
    |May 1, 1978
    PubMed
    Summary

    Mouse shock sensitivity remains consistent during early development. Researchers found that young mice aged 5 to 15 days exhibited similar responses to varying electric shock intensities, suggesting stable motivational properties of shock.

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    Area of Science:

    • Neuroscience
    • Developmental Psychology
    • Animal Behavior

    Background:

    • Understanding the developmental trajectory of sensory processing is crucial for identifying age-related changes.
    • Investigating the aversiveness of stimuli like electric shock provides insights into pain perception and avoidance behaviors.
    • Early life experiences can shape neural pathways and behavioral responses.

    Purpose of the Study:

    • To assess the escape and avoidance responses of developing mice to varying intensities of electric shock.
    • To compare the effectiveness of constant current and fixed impedance shock sources in eliciting behavioral responses.
    • To determine if shock aversiveness changes across early developmental stages in mice.

    Main Methods:

    • A spatial-preference technique was employed to test mice aged 5, 7, 9, 11, 13, and 15 days.
    • Electric shock intensities were administered using both AC constant current (0-0.2 mA) and fixed impedance (0-70 V) shock sources.
    • Escape and avoidance behaviors were recorded and analyzed across different ages and shock intensities.

    Main Results:

    • Near-asymptotic escape and avoidance responses were observed at 0.1 mA for the constant current source and 50 V for the fixed impedance source.
    • Few age-related differences in the relative aversiveness of specific shock intensities were found.
    • The fixed impedance shock source resulted in more consistent avoidance behavior compared to the constant current source.

    Conclusions:

    • The motivational properties of electric shock appear to be stable throughout early mouse development (5-15 days of age).
    • The spatial-preference technique is a viable method for assessing age-related alterations in shock sensitivity.
    • This methodology can be utilized to study the impact of physiological or pharmacological manipulations on shock sensitivity during development.

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