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Simultaneous treatment with terbutaline and theophylline
European Journal of Respiratory Diseases. Supplement
|January 1, 1984
Summary
Theophylline and terbutaline provide additive bronchodilation in asthma patients. Combining these drugs at comparable effects resulted in fewer side effects than using either medication alone.
Area of Science:
- Pharmacology
- Respiratory Medicine
- Clinical Therapeutics
Background:
- Asthma management often involves bronchodilators.
- Theophylline and beta-2 agonists are common asthma medications.
- Understanding their combined effects and side effects is crucial.
Purpose of the Study:
- To investigate the bronchodilating effects of theophylline and terbutaline.
- To assess the side effects of these drugs alone and in combination.
- To determine if combining theophylline and terbutaline offers therapeutic advantages.
Main Methods:
- 10 adult asthmatic patients participated.
- Theophylline was administered to achieve steady-state plasma concentrations (0, 7.5, 15 µg/mL).
- Terbutaline was given intravenously, and effects on FEV1, heart rate, and tremor were measured.
Main Results:
- Theophylline increased FEV1 in a dose-dependent manner.
- Terbutaline also increased FEV1, heart rate, and tremor.
- The combination demonstrated additive bronchodilation.
- At equivalent bronchodilation, the combination had fewer side effects than monotherapy.
Conclusions:
- Theophylline and terbutaline have additive bronchodilating effects.
- Combining theophylline and terbutaline may be a viable strategy for asthma treatment.
- This combination potentially offers improved efficacy with reduced side effects compared to individual drugs.