Prostaglandin E2 excretion in spinal cord injury patients

Hyponatremia has proven to be a common finding in spinal cord injured (SCI) patients. Mechanisms exist whereby SCI patients with either normal or impaired renal function may develop it. One such mechanism may be an impairment in prostaglandin (PGE2) excretion resulting in unopposed activity of antidiuretic hormone (ADH). Paired 24-hour urine collections for PGE2 were collected from SCI patients with varying degrees of renal dysfunction. There was a wide interpatient variability in the excretion of PGE2, with no significant correlation of PGE2 excretion in respect to either urine volume, urine sodium concentration, or the degree of renal dysfunction.