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Updated: May 4, 2026
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Standardized Measurement of Nasal Membrane Transepithelial Potential Difference NPD
Published on: September 13, 2018
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Transmucosal potential difference; diagnostic value in gastro-oseophageal reflux.
Gut
|May 1, 1978
Summary
Measuring transmucosal potential difference (PD) in the lower esophagus is a rapid and sensitive method for detecting esophageal mucosal damage. This objective index correlates well with symptoms like dysphagia and heartburn, aiding in reflux diagnosis.
Area of Science:
- Gastroenterology
- Esophageal Physiology
Background:
- Upper gastrointestinal diseases present with various symptoms.
- Endoscopy is a common diagnostic tool, but objective measures of esophageal health are valuable.
Purpose of the Study:
- To evaluate the utility of transmucosal potential difference (PD) measurement in diagnosing lower esophageal mucosal damage.
- To correlate PD measurements with histological findings and patient symptoms.
Main Methods:
- Nineteen patients with upper GI symptoms underwent endoscopy.
- Transmucosal potential difference (PD) was measured in the lower esophagus.
- Biopsy specimens were obtained for histological examination (hematoxylin and eosin staining).
Main Results:
- Patients with normal esophageal histology had a mean PD of -14.4 mV.
- Patients with reflux-related histological changes showed a mean PD of +9.4 mV, with reversed polarity in most cases.
- PD measurements correlated well with symptoms like dysphagia and heartburn, outperforming visual endoscopic assessment.
Conclusions:
- Transmucosal potential difference (PD) measurement is a simple, rapid, and sensitive method for detecting esophageal mucosal damage.
- PD offers an objective index for diagnosing lower esophageal disease, complementing symptom assessment.
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