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Related Experiment Video

Updated: Jan 6, 2026

Two-dimensional Porcine Intestinal Organoids Reflecting the Physiological Properties of Native Gut
09:13

Two-dimensional Porcine Intestinal Organoids Reflecting the Physiological Properties of Native Gut

Published on: January 31, 2025

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Motilin release in the pig.

I M Modlin, P Mitznegg, S R Bloom

    Gut
    |May 1, 1978
    PubMed
    Summary

    Gastric acid stimulates motilin release in pigs, a local intestinal event. This hormone

    Area of Science:

    • Gastroenterology
    • Endocrinology
    • Physiology

    Background:

    • Motilin is a gastrointestinal hormone found in the upper intestine of pigs and humans.
    • In humans, motilin release is triggered by gastric acid.
    • The release mechanism and physiological role of motilin in pigs are not well understood.

    Purpose of the Study:

    • To investigate the release of motilin in pigs in response to gastric acid stimulation.
    • To determine the location and characteristics of motilin release in the pig's upper small intestine.
    • To explore the potential physiological role of motilin in pigs.

    Main Methods:

    • Gastric acid was introduced into the upper small intestine of pigs to stimulate motilin release.
    • Plasma motilin levels were measured before, during, and after stimulation.

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  • Immunohistochemistry was used to assess motilin levels in the intestinal tissue.
  • Vascular occlusion of the stimulated segment was performed to assess the local nature of release.

    • Main Results:

    • Gastric acid administration in pigs led to a significant increase in plasma motilin levels.
    • This increase was associated with a marked reduction in immunostainable motilin in the upper small intestine.
    • Occluding the blood supply to the stimulated intestinal segment immediately halted the rise in plasma motilin, confirming a local release.
    • The apparent half-life of endogenous motilin was determined to be 3.9 minutes.
    • No motilin release was observed after a meal in pigs.

    Conclusions:

    • Motilin release in pigs is a local phenomenon in the upper small intestine, triggered by gastric acid.
    • The rapid clearance and lack of post-meal release suggest a specialized, yet currently speculative, physiological role for motilin in pigs.
    • Further research is needed to elucidate the precise function of motilin in porcine gastrointestinal physiology.