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The barrier function of the posterior capsule
Journal - American Intra-Ocular Implant Society
|January 1, 1984
Summary
The rabbit and human cataractous lens posterior capsule allows epinephrine, ultraviolet, and visible light to pass through. However, it acts as a barrier to other large or negatively charged molecules like trypan blue.
Area of Science:
- Ophthalmology
- Biomedical Engineering
- Materials Science
Background:
- The lens posterior capsule's permeability is crucial for drug delivery and understanding ocular conditions.
- Cataractous changes may alter the posterior capsule's barrier properties.
Purpose of the Study:
- To investigate the in vitro permeability of rabbit and human cataractous lens posterior capsules.
- To assess the passage of epinephrine, trypan blue, UV, and visible light through the posterior capsule.
Main Methods:
- In vitro study using rabbit and human cataractous lens posterior capsules.
- Permeability assays for epinephrine and trypan blue.
- Spectrophotometric analysis for UV and visible light absorption.
Main Results:
- The posterior capsule effectively blocked large non-electrolytes and negative electrolytes (except trypan blue).
- Epinephrine, ultraviolet light, and visible light passed through the posterior capsule unimpeded.
- Trypan blue showed limited permeability, suggesting some barrier function against it.
Conclusions:
- The posterior capsule exhibits selective permeability, allowing passage of small molecules and light.
- Findings have implications for targeted drug delivery and optical properties in cataract research.
- The posterior capsule's barrier function is molecule-dependent.