Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Abnormal norepinephrine release in uremia.

J L Izzo, R H Sterns

    Kidney International. Supplement
    |December 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Uremic patients exhibit sympathetic nervous hyperactivity due to increased norepinephrine release. Impaired negative feedback from circulating norepinephrine may contribute to this condition in uremia.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Hypertension and aging in rural Haiti: results from a preliminary survey.

    Journal of human hypertension·2016
    Same author

    Comparative effects of glucagon, hydrocortisone and epinephrine on the protein metabolism of the fasting rat.

    UR [reports]. U.S. Atomic Energy Commission·2014
    Same author

    Office and ambulatory pulse pressure--association with clinical characteristics and cardiovascular risk factors in normoalbuminuric patients with type 2 diabetes (ROADMAP study).

    Journal of human hypertension·2010
    Same author

    Comparative efficacy and safety of amlodipine/benazepril combination therapy and amlodipine monotherapy in severe hypertension.

    Journal of human hypertension·2009
    Same author

    Determinants of urinary albumin excretion within the normal range in patients with type 2 diabetes: the Randomised Olmesartan and Diabetes Microalbuminuria Prevention (ROADMAP) study.

    Diabetologia·2009
    Same author

    Seasonal variation in haemodynamics and blood pressure-regulating hormones.

    Journal of human hypertension·2009
    Same journal

    Effect of kidney disease on glucose handling (including genetic defects).

    Kidney international. Supplement·2011
    Same journal

    Need for better diabetes treatment for improved renal outcome.

    Kidney international. Supplement·2011
    Same journal

    Glucose dynamics and mechanistic implications of SGLT2 inhibitors in animals and humans.

    Kidney international. Supplement·2011
    Same journal

    SGLT2 inhibitors: molecular design and potential differences in effect.

    Kidney international. Supplement·2011
    Same journal

    Glucose handling by the kidney.

    Kidney international. Supplement·2011
    Same journal

    Bone: from a reservoir of minerals to a regulator of energy metabolism.

    Kidney international. Supplement·2011
    See all related articles

    Area of Science:

    • Nephrology
    • Cardiovascular Physiology
    • Neuroendocrinology

    Background:

    • Sympathetic nervous system (SNS) activity is crucial for cardiovascular regulation.
    • Uremia is associated with cardiovascular complications, potentially linked to SNS dysfunction.
    • Norepinephrine (NE) is a key neurotransmitter and hormone reflecting SNS activity.

    Purpose of the Study:

    • To investigate sympathetic nervous activity in uremic patients compared to healthy controls.
    • To determine if NE metabolism and release are altered in uremia.
    • To explore the role of NE in potential feedback mechanisms regulating SNS activity.

    Main Methods:

    • Utilized two-step steady-state cold norepinephrine (NE) infusions in normal men and uremic patients.
    • Measured basal venous NE levels.

    Related Experiment Videos

  • Calculated NE metabolic clearance rate (CNE) and NE appearance rate in plasma.

    • Main Results:

    • Uremic patients showed higher basal venous NE and NE metabolic clearance rate (CNE) compared to controls.
    • The calculated NE appearance rate in plasma was significantly higher in uremic patients, indicating increased NE release.
    • Controls exhibited a decrease in CNE and NE appearance rate at higher NE infusion rates, unlike uremic patients.

    Conclusions:

    • Uremic patients demonstrate sympathetic nervous hyperactivity, characterized by increased NE release.
    • Circulating NE may normally exert negative feedback on SNS activity.
    • This negative feedback mechanism appears to be impaired in patients with uremia.