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Related Experiment Videos

Bromine in human tissue.

J D Cross, H Smith

    Forensic Science
    |March 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    This study establishes normal human tissue bromine levels and a bromine-to-chlorine ratio to detect overexposure. Bromine in hair can indicate ingestion time, though multiple doses complicate interpretation due to its long half-life.

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    Area of Science:

    • Toxicology
    • Human Physiology
    • Analytical Chemistry

    Background:

    • Bromine is a naturally occurring element found in human tissues.
    • Understanding normal bromine levels is crucial for assessing potential overexposure.
    • Trace element distribution patterns in the body offer insights into exposure and metabolism.

    Purpose of the Study:

    • To define normal bromine concentrations in human tissues.
    • To establish a reliable indicator for bromine overexposure.
    • To explore the utility of hair bromine analysis for determining ingestion timing.

    Main Methods:

    • Quantification of bromine and chlorine levels in human tissue samples.
    • Calculation of the bromine (microgram) to chlorine (mg) ratio.

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  • Analysis of bromine concentrations in hair sections.

    • Main Results:

    • A bromine to chlorine ratio of 3.2 was identified as a threshold for considering bromine overexposure.
    • Bromine concentrations in hair segments can correlate with the timing of ingestion, even for small doses.
    • The long biological half-life of bromine (approximately 15 days) in human tissue can complicate the interpretation of results following multiple exposures.

    Conclusions:

    • The bromine to chlorine ratio serves as a valuable tool for identifying potential bromine overexposure.
    • Hair analysis offers a method for estimating the timing of bromine intake.
    • Challenges in interpreting bromine levels after multiple doses necessitate careful consideration of the element's long half-life.