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Confirming evidence for the clonal development and stem cell origin of Philadelphia chromosome-negative chronic
American Journal of Hematology
|July 1, 1984
Abstract:
A 74-year old woman with Ph1-negative chronic myelogenous leukemia (CML) and heterozygous for glucose-6-phosphate dehydrogenase (G6PD) was studied. Both A and B types of G6PD were found in skin. In contrast, white blood cells and platelets showed only a single G6PD type A. These results provide further evidence that Ph1-negative CML has a stem cell origin and develops clonally.