[Effect of naproxen on the thrombocyte bleeding time and on the anticoagulant treatment with phenprocoumon]

With a dose of 250 mg b.i.d. naproxen causes a slight, apparently clinically not relevant alteration of the primary bleeding pattern. Against phenprocoumon, naproxen has a transient hypoprothrombinemic effect which is followed by a short phase of increased tolerance. A further influence on anticoagulant therapy is not shown.