HLA, Gm and endocrine diseases

Differences in the frequency rates of seven signs determined by locus HLA-A and of 14 signs controlled by the HLA-B locus and also differences in the rates of appearance of four signs of the Gm system and that of the Inv(1) sign were searched for between patients suffering from diseases of the thyroid gland and healthy subjects. No statistically significant differences in the HLA system could be demonstrated when healthy subjects were compared to the diseased patients. In simple goiter patients there was a significant difference in the frequency rates of the Gm (1, 4, 5) phenotypes and a highly significant difference in the frequency rates of the Gm (1, 2, 4, 5) phenotypes. No direct association could be demonstrated between the above mentioned systems and the studied disease.