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[Pefloxacine: diffusion into bronchial mucus].

C Morel, M Vergnaud, M Langeard

    Pathologie-Biologie
    |June 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

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    Pefloxacin, a broad-spectrum quinolone antibiotic, shows excellent diffusion into bronchial mucus. Drug concentrations in mucus were high and comparable to plasma levels, indicating outstanding penetration.

    Area of Science:

    • Pharmacology
    • Microbiology
    • Respiratory Medicine

    Context:

    • Antibiotic therapy for respiratory infections.
    • Understanding drug penetration into respiratory tissues is crucial for effective treatment.
    • Pefloxacin is a fluoroquinolone with broad-spectrum antibacterial activity.

    Purpose:

    • To evaluate the diffusion of pefloxacin into bronchial mucus.
    • To determine pefloxacin concentrations in mucus and plasma over time.
    • To assess the ratio of mucus to plasma concentrations.

    Summary:

    • Pefloxacin was administered to 35 patients, with sputum and plasma samples collected at various time points.
    • Microbiological assays revealed high mean pefloxacin concentrations in bronchial mucus, frequently exceeding 5 mg/l.

    Related Experiment Videos

  • Mucus concentrations were consistently high and similar on days 1 and 3, with mucus-to-plasma concentration ratios often at or above 1.

    • Impact:

    • Demonstrates outstanding diffusion of pefloxacin into bronchial mucus.
    • Suggests potential efficacy of pefloxacin in treating respiratory tract infections involving mucus.
    • Provides valuable pharmacokinetic data for optimizing pefloxacin dosing in respiratory conditions.