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[Pefloxacine: diffusion into bronchial mucus]
Abstract:
Pefloxacin is a new quinolone with significant in vitro antibacterial activity and a broad spectrum. It was included in an extensive study of antibiotic diffusion into bronchial mucus. Pefloxacin was given to 35 patients divided into five groups according to the timing of sputum sampling. Plasma specimens were taken simultaneously. Pefloxacin was measured by microbiological assay. Mean pefloxacin concentrations in bronchial mucus was high, exceeding 5 mg/l. Concentrations on the first and third days were similar. The ratio of mucus concentrations to plasma concentrations was high in each case, around or often above 1. These findings show that diffusion of pefloxacin into bronchial mucus is outstanding.
Insights
Pefloxacin, a broad-spectrum quinolone antibiotic, shows excellent diffusion into bronchial mucus. Drug concentrations in mucus were high and comparable to plasma levels, indicating outstanding penetration.
Area of Science:
- Pharmacology
- Microbiology
- Respiratory Medicine
Context:
- Antibiotic therapy for respiratory infections.
- Understanding drug penetration into respiratory tissues is crucial for effective treatment.
- Pefloxacin is a fluoroquinolone with broad-spectrum antibacterial activity.
Purpose:
- To evaluate the diffusion of pefloxacin into bronchial mucus.
- To determine pefloxacin concentrations in mucus and plasma over time.
- To assess the ratio of mucus to plasma concentrations.
Summary:
- Pefloxacin was administered to 35 patients, with sputum and plasma samples collected at various time points.
- Microbiological assays revealed high mean pefloxacin concentrations in bronchial mucus, frequently exceeding 5 mg/l.
- Mucus concentrations were consistently high and similar on days 1 and 3, with mucus-to-plasma concentration ratios often at or above 1.
Impact:
- Demonstrates outstanding diffusion of pefloxacin into bronchial mucus.
- Suggests potential efficacy of pefloxacin in treating respiratory tract infections involving mucus.
- Provides valuable pharmacokinetic data for optimizing pefloxacin dosing in respiratory conditions.