Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hereditary sclerosing poikiloderma.

K E Greer, P E Weary, R Nagy

    International Journal of Dermatology
    |May 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    BAHA Attract to Osia conversion patients: comparison of the two systems and long-term outcomes.

    The Journal of laryngology and otology·2022
    Same author

    Low-dose ipilimumab plus nivolumab combined with IL-2 and hyperthermia in cancer patients with advanced disease: exploratory findings of a case series of 131 stage IV cancers - a retrospective study of a single institution.

    Cancer immunology, immunotherapy : CII·2020
    Same author

    Citrobacter freundii as a test platform for recombinant cellulose degradation systems.

    Letters in applied microbiology·2016
    Same author

    A simple medium for continuous subculture of Pityrosporum orbiculare.

    The Journal of investigative dermatology·2015
    Same author

    Absence of keratinolytic activity in three strains of Candida albicans.

    The Journal of investigative dermatology·2015
    Same author

    Taxane associated subacute cutaneous lupus erythematosus.

    Dermatology online journal·2013
    Same journal

    Correlation of Clinical and Histopathological Features With Anti-Desmoglein Antibody Profile in Pemphigus Patients.

    International journal of dermatology·2026
    Same journal

    Clinicopathological Challenge: A Painful Violaceous Reticulated Patch.

    International journal of dermatology·2026
    Same journal

    Editor's Highlights-August 2026.

    International journal of dermatology·2026
    Same journal

    Preliminary Validation of the Early Sacroiliitis Screening Tool (ESHST) for Identifying Hidradenitis Suppurativa Patients at High Risk of Spondyloarthritis.

    International journal of dermatology·2026
    Same journal

    Efficacy of Intralesional Bevacizumab Versus Intralesional Triamcinolone Acetonide Injection in the Treatment of Keloids: A Randomized Clinical Trial.

    International journal of dermatology·2026
    Same journal

    Evaluation of Intralesional Bleomycin and Triamcinolone Acetonide in the Treatment of Keloids: A Prospective, Randomized, Open-Label, Comparative Study.

    International journal of dermatology·2026
    See all related articles

    This study investigated hereditary sclerosing poikiloderma, a rare genetic skin disorder. Researchers found no clear mechanism explaining the cause of the observed clinical and histological skin changes.

    Area of Science:

    • Dermatology
    • Genetics
    • Pathology

    Background:

    • Hereditary sclerosing poikiloderma is a rare, dominantly inherited genodermatosis.
    • The clinical and histological features of this disorder are striking but poorly understood.
    • Investigating the underlying mechanism is crucial for potential therapeutic strategies.

    Observation:

    • Three individuals with hereditary sclerosing poikiloderma were examined.
    • Clinical presentation included striking cutaneous lesions.
    • Histological examination revealed characteristic changes in the skin.

    Findings:

    • Comprehensive investigations were performed, including blood chemistry, chromosome analysis, and skin biopsies.
    • Skin biopsies were analyzed using routine stains, electron microscopy, and direct immunofluorescence.

    Related Experiment Videos

  • No specific mechanism was identified to explain the pathogenesis of the cutaneous lesions.

    • Implications:

    • The study highlights the current lack of understanding regarding the etiology of hereditary sclerosing poikiloderma.
    • Further research is needed to elucidate the genetic and molecular pathways involved.
    • Identifying the mechanism could pave the way for targeted treatments for this rare disorder.