Negative symptoms and platelet monoamine oxidase activity in male schizophrenic patients

A significant positive correlation was found between negative symptoms and platelet monoamine oxidase (MAO) activity in unmedicated male, but not female, schizophrenic patients. This correlation was significant in split halves of the male patients. There was no indication that the correlation was due to either outliers or medication effects. Male schizophrenic patients with high negative symptom scores had significantly higher mean platelet MAO activity than either male normal control subjects or male schizophrenic patients with low negative symptom scores. This finding suggests that the extent of negative symptoms in a population of males could affect whether the schizophrenic subjects will be found to have platelet MAO activity which differs from that of normal control subjects. The implications of the correlation between platelet MAO activity and negative symptoms for the role of brain MAO activity and two of its substrates, dopamine and serotonin, in the etiology of negative symptoms in male schizophrenic patients are discussed.