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[Adjuvant chemotherapy for osteosarcoma in Japan--past, present and future]
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|September 1, 1984
Summary
Before 1970, osteosarcoma treatment yielded poor results in Japan. Intensive multi-drug chemotherapy has since improved survival rates, making limb-saving surgery more feasible.
Area of Science:
- Orthopedic Oncology
- Medical History
Context:
- Osteosarcoma treatment in Japan before 1970 showed discouraging therapeutic results.
- Introduction of regional perfusion (1960) and intraarterial infusion (1963) techniques improved outcomes.
- Initial five-year survival rates reached approximately 30% between 1971-1976.
Purpose:
- To review the evolution of osteosarcoma treatment in Japan.
- To highlight the impact of chemotherapy on survival rates and surgical approaches.
Summary:
- Intensive multi-drug adjuvant chemotherapy has significantly increased the five-year disease-free survival rate for osteosarcoma in Japan, projected to exceed 50%.
- Data from the Japanese Osteosarcoma Research Group (JOOG) and the Group Study of Osteosarcoma (GSO) support these findings.
- While ablative surgery remains standard, preoperative chemotherapy enables limb-saving operations.
Impact:
- Advances in chemotherapy have transformed osteosarcoma management, improving patient survival.
- The shift towards limb-saving surgery represents a major advancement in reconstructive orthopedic oncology.
- Future research may further refine chemotherapy regimens and surgical techniques for better osteosarcoma outcomes.