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Neutrophils with ring-shaped nuclei in myeloproliferative disease
Abstract:
Neutrophils with ring-shaped nuclei were found in 12 out of 28 patients with myeloproliferative disease and only rarely in patients with toxaemic granulocytosis and in healthy controls. Nuclear ring formation and hyposegmentation appeared to be significantly related. Recently we became aware of the occasional occurrence of neutrophils with ring-shaped nuclei in patients with myelodysplastic syndromes (MDS) and in chronic granulocytic leukaemia (CGL). Ring formation is a well-known feature of granulopoiesis in rodents. To our knowledge it has not been described in man. We therefore report here on a search for ring neutrophils in peripheral blood smears of patients and controls.
Insights
Ring neutrophils, characterized by ring-shaped nuclei, were frequently observed in myeloproliferative disease patients. This finding suggests a potential diagnostic marker for specific blood disorders in humans.
Area of Science:
- Hematology
- Cell Biology
- Oncology
Background:
- Neutrophils with ring-shaped nuclei are a known feature of granulopoiesis in rodents.
- This specific nuclear morphology has not been previously well-described in human peripheral blood.
- Preliminary observations noted ring neutrophils in myelodysplastic syndromes (MDS) and chronic granulocytic leukemia (CGL).
Purpose of the Study:
- To investigate the occurrence and significance of neutrophils with ring-shaped nuclei in human peripheral blood.
- To determine the prevalence of ring neutrophils in patients with myeloproliferative disease compared to controls.
Main Methods:
- Systematic examination of peripheral blood smears.
- Analysis of neutrophil morphology, specifically focusing on nuclear ring formation and hyposegmentation.
- Comparison of ring neutrophil frequency between patients with myeloproliferative disease, toxaemic granulocytosis, myelodysplastic syndromes, chronic granulocytic leukaemia, and healthy controls.
Main Results:
- Neutrophils with ring-shaped nuclei were identified in 12 out of 28 patients diagnosed with myeloproliferative disease.
- Ring neutrophils were found rarely in patients with toxaemic granulocytosis and in healthy individuals.
- A significant association was observed between nuclear ring formation and hyposegmentation of neutrophil nuclei.
Conclusions:
- The presence of neutrophils with ring-shaped nuclei is significantly more common in patients with myeloproliferative disease.
- This morphological finding may serve as a potential indicator in the diagnosis of myeloproliferative neoplasms.
- Further research is warranted to fully elucidate the clinical implications of ring neutrophils in human hematology.