Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

The hematocrit-erythrocyte-disaggregation-apparatus (HEDA).

H Kiesewetter, C Mrowietz, H Lazar

Biorheology. Supplement : the Official Journal of the International Society of Biorheology

|January 1, 1984

Summary

Researchers created a device to measure red blood cell (erythrocyte) disaggregation force and hematocrit. A consistent relationship was found between shear force and hematocrit in normal blood samples.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Effects of Arthrospira platensis-derived phycocyanin on blood cells1.

Clinical hemorheology and microcirculation·2022

Same author

Differences in human and sheep platelet adherence, aggregation and activation induced by glass beads in a modified chandler loop-system.

Clinical hemorheology and microcirculation·2021

Same author

Differences in human and minipig platelet number, volume and activation induced by borosilicate glass beads in a modified chandler loop-system.

Clinical hemorheology and microcirculation·2021

Same author

Cutaneous microcirculation in patients with peripheral arterial occlusive disease: Comparison of capillary blood circulation in the nail fold of finger and toe.

Clinical hemorheology and microcirculation·2020

Same author

HELP-(Heparin-induced Extracorporeal LDL Precipitation)-apheresis in heart recipients with cardiac allograft vasculopathy and concomitant hypercholesterolemia: Influence of long-term treatment on the microcirculation.

Clinical hemorheology and microcirculation·2019

Same author

Growth-related micromorphological characteristics of the porcine femoral artery.

Clinical hemorheology and microcirculation·2019

Area of Science:

Biomedical Engineering
Hematology
Fluid Mechanics

Background:

Accurate hematocrit determination is crucial for diagnosing various medical conditions.
Understanding erythrocyte behavior under shear stress is vital for blood flow studies.

Purpose of the Study:

To develop a novel device for measuring the minimum shear force required for erythrocyte disaggregation.
To establish a functional relationship between this shear force and blood hematocrit.
To investigate the consistency of this relationship across normal blood samples.

Main Methods:

Development of a specialized device to apply controlled shear forces to blood samples.
Simultaneous measurement of the minimum shear force for complete erythrocyte disaggregation and hematocrit.
Analysis of the functional relationship between shear force and hematocrit.

Main Results:

A reproducible functional relationship was established between the minimum shear force and hematocrit.
The first derivative of the measured shear force (gamma Tmin) with respect to hematocrit was found to be consistent across all tested normal blood samples.
This indicates a predictable mechanical behavior of erythrocytes related to their concentration.

Conclusions:

The developed device offers a reliable method for simultaneous determination of erythrocyte disaggregation force and hematocrit.
The consistent relationship observed has implications for understanding blood rheology and developing diagnostic tools.
The findings suggest a potential biomarker for assessing red blood cell properties.

Related Experiment Videos