Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changing metastatic patterns of osteosarcoma.

A E Giuliano, S Feig, F R Eilber

    Cancer
    |November 15, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    FOXC1: an emerging marker and therapeutic target for cancer.

    Oncogene·2017
    Same author

    FOXC1 is involved in ERα silencing by counteracting GATA3 binding and is implicated in endocrine resistance.

    Oncogene·2016
    Same author

    Long-term clinical impact of sentinel lymph node biopsy in breast cancer and cutaneous melanoma.

    The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...·2014
    Same author

    Assessment of DNA methylation status in early stages of breast cancer development.

    British journal of cancer·2013
    Same author

    FOXC1 regulates the functions of human basal-like breast cancer cells by activating NF-κB signaling.

    Oncogene·2012
    Same author

    Volume-controlled vs no/short-term drainage after axillary lymph node dissection in breast cancer surgery: a meta-analysis.

    Breast (Edinburgh, Scotland)·2009
    Same journal

    Real-world effectiveness of chemotherapy regimens after immunotherapy in patients with advanced melanoma in Spain: Results from the GEM1801 study.

    Cancer·2026
    Same journal

    Bendamustine in indolent lymphoma: Letting the dust settle down.

    Cancer·2026
    Same journal

    Top advances of the year: Bispecific antibodies in early lines of therapy in multiple myeloma.

    Cancer·2026
    Same journal

    Direct oral anticoagulants and warfarin in atrial fibrillation patients with cancer by anticoagulation quality.

    Cancer·2026
    Same journal

    Sexual orientation and gender identity based disparities in colorectal, cervical, and breast cancer screening in the United States.

    Cancer·2026
    Same journal

    Toward exercise as standard care for older cancer survivors.

    Cancer·2026
    See all related articles

    Treatment advances for osteosarcoma have shifted recurrence patterns. While pulmonary metastases were once dominant, adjuvant chemotherapy now correlates with increased extrapulmonary and simultaneous metastases in osteosarcoma patients.

    Area of Science:

    • Oncology
    • Orthopedic Surgery
    • Medical History

    Background:

    • Osteosarcoma is a primary bone malignancy with a propensity for distant metastasis.
    • Understanding the evolution of its natural history and metastatic patterns is crucial for treatment optimization.

    Purpose of the Study:

    • To review the clinical courses of osteosarcoma patients treated over a decade.
    • To ascertain changes in the natural history and metastatic patterns of high-grade intraosseous osteosarcoma.

    Main Methods:

    • Retrospective review of 111 patients with high-grade intraosseous osteosarcoma treated between 1971 and 1982.
    • Exclusion of specific subtypes like low-grade, facial, or Paget's disease-associated osteosarcomas.
    • Comparison of metastatic patterns between patients treated with amputation alone versus surgery with adjuvant chemotherapy.

    Related Experiment Videos

    Main Results:

    • Pulmonary metastases were the most common initial recurrence site (36/59 patients).
    • Patients treated with surgery and adjuvant chemotherapy (post-1974) showed a lower rate of isolated pulmonary recurrence (45%) compared to amputation alone (94.7%).
    • Adjuvant chemotherapy correlated with an increase in initial extrapulmonary metastases (27.5%) and simultaneous pulmonary/extrapulmonary metastases.

    Conclusions:

    • The metastatic pattern of osteosarcoma appears to be evolving.
    • Nonpulmonary metastases are becoming more prevalent in contemporary osteosarcoma treatment.
    • While not solely attributable to chemotherapy, adjuvant therapy may influence the site of osteosarcoma recurrence.