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Sex selection by sperm separation and insemination.

S L Corson, F R Batzer, N J Alexander

Fertility and Sterility

|November 1, 1984

Summary

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This study demonstrates sperm separation techniques can enrich for Y or X sperm, enabling couples to select the sex of their infant. The albumin filtration method achieved 80% male births, while Sephadex gel filtration showed promise for female selection.

Area of Science:

Reproductive biology
Genetics
Medical technology

Background:

Sperm sorting techniques are crucial for reproductive choices and preventing sex-linked genetic disorders.
Selective insemination aims to control offspring sex based on parental preference or medical necessity.

Purpose of the Study:

To evaluate the efficacy of sperm separation methods for sex selection in human conception.
To determine the success rates of achieving desired offspring sex using albumin and Sephadex gel filtration.

Main Methods:

The Ericsson albumin filtration technique was employed to isolate Y-chromosome-bearing sperm for male-biased insemination.
A Sephadex gel filtration system was utilized to enrich for X-chromosome-bearing sperm for female-biased insemination.

Keywords:

Artificial Insemination Biology Demographic Factors Examinations And Diagnoses Genetics Genitalia Genitalia, Male Germ Cells Laboratory Examinations And Diagnoses Neonatal Diseases And Abnormalities Pennsylvania Physiology Population Population Dynamics Reproduction Reproductive Technologies Semen--analysis Seminal Vesicles Sex Preselection Spermatozoa Time Factors Urogenital System

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Main Results:

Using albumin filtration, 35 conceptions resulted in 28 males (80%).
With Sephadex gel filtration, 12 pregnancies yielded 7 females, 2 males, and 1 set of twins (one of each sex).

Conclusions:

Sperm separation techniques offer a viable method for elective sex selection.
Female sex selection is also indicated for avoiding the transmission of sex-linked diseases in carrier mothers.