Recurrent testicular infiltrates following radiation therapy for lymphoid malignancy

From a group of 28 patients with biopsy-proven testicular leukemia seen at our institution since 1979, we describe two boys with lymphoid malignancy who, subsequent to 1,800 rad and 2,400 rad testicular radiation, had second overt testicular relapses. This experience suggests that these patients need careful follow-up physical examinations, that higher doses may be needed for prolonged local control, and that there may be a role for follow-up testicular biopsies.