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Updated: Aug 19, 2026

In Vitro Method to Control Concentrations of Halogenated Gases in Cultured Alveolar Epithelial Cells
Published on: October 23, 2018
Cardio-respiratory changes and prostaglandins during one-lung-anesthesia
Abstract:
In a clinical study the intraoperative changes in prostaglandin levels and their possible influence on venous admixture during one-lung anesthesia are investigated in 9 patients undergoing abdomino-thoracic resection of a carcinoma of the oesophagus. During one-lung anesthesia PaO2 decreased and Qsp/Qt increased significantly. In 7 of the 9 patients prostaglandin E2 in the arterial blood was significantly above normal level during two-lung- and one-lung ventilation, prostaglandin F2 alpha was below normal values in all patients during two-lung- and one-lung ventilation. The clear prevalence of vasodilating prostaglandin E2 may have reduced the effectiveness of hypoxic pulmonary vasoconstriction during one-lung ventilation.
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