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Changes in the SHBG concentration during danazol treatment
Acta Obstetricia Et Gynecologica Scandinavica. Supplement
|January 1, 1984
Summary
Danazol significantly reduces sex hormone-binding globulin (SHBG) levels in women, with dose-dependent effects. This suggests danazol directly inhibits SHBG production in the liver.
Area of Science:
- Endocrinology
- Pharmacology
Background:
- Sex hormone-binding globulin (SHBG) is a key protein in regulating sex steroid bioavailability.
- Danazol is a synthetic steroid with various therapeutic applications.
Purpose of the Study:
- To investigate the effect of danazol on serum SHBG levels in pre- and postmenopausal women.
- To determine the dose-dependency and time course of danazol's impact on SHBG synthesis.
Main Methods:
- Radioelectro-immunoassay was used to measure SHBG levels.
- Danazol was administered in daily doses ranging from 200 to 800 mg for 1-6 months.
- SHBG half-life was calculated using linear regression analysis.
Main Results:
- Danazol caused a rapid, dose-dependent decrease in SHBG levels in both pre- and postmenopausal women.
- SHBG levels reached a new steady state at 20-30% of original concentrations after one month.
- The calculated half-life of SHBG was approximately 15 days.
Conclusions:
- Danazol directly inhibits hepatic synthesis of SHBG.
- The effect is dose-dependent and independent of estrogen levels.
- Endogenous androgens may accentuate danazol's inhibitory effect on SHBG.