Typing of HLA antigens in a child population with nephrosis syndrome

Using the microlymphocytotoxicity test of Terasaki, HLA--A, B, Cw antigen typing was done for 37 antigens in 28 children with steroid-sensitive nephrosis and five children with steroid-resistant nephrosis. Evaluation was made by the chi 2 test as corrected by the method of Yeates. In steroid-sensitive nephrosis the frequency of HLA--B 8 antigen was 33.3% and in the resistant cases 40% as against 18.5% in the controls. The difference, however, was not significant, the B 12 and B 13 antigens were more frequent in both steroid-sensitive and resistant nephrosis, though not significantly.