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High density lipoprotein cholesterol and apoprotein A1 in healthy volunteers during long-term moderate alcohol intake
Insights
Moderate alcohol intake for 5 weeks positively impacts lipoproteins. High-density lipoprotein (HDL) cholesterol and apoprotein A1 levels increased, suggesting potential cardiovascular benefits from moderate alcohol consumption.
Area of Science:
- Cardiovascular Science
- Nutritional Biochemistry
- Lipid Metabolism
Background:
- Moderate alcohol consumption is linked to reduced cardiovascular mortality.
- High-density lipoprotein (HDL) cholesterol levels are inversely predictive of coronary heart disease.
- Understanding alcohol's impact on lipoproteins is crucial for cardiovascular health.
Purpose of the Study:
- To investigate the effects of 5 weeks of moderate alcohol intake on lipoprotein profiles in normal men.
- To specifically examine changes in high-density lipoprotein (HDL) cholesterol and its associated apoproteins (A, A1, B).
Main Methods:
- A study involving 7 healthy male participants.
- Monitoring of lipoprotein levels, including HDL cholesterol, apoprotein A1, and apoprotein B.
- Utilized heparin manganese precipitation and phosphotungstate magnesium methods for HDL cholesterol analysis.
Main Results:
- Significant increase in high-density lipoprotein (HDL) cholesterol levels (p < 0.01).
- Modification of HDL composition, including increased esterified/total cholesterol ratio and phospholipids (p < 0.05).
- Significant increase in apoprotein A1 (p < 0.05) and a transient rise in apoprotein A, with no significant change in apoprotein B or other lipoproteins.
Conclusions:
- Moderate alcohol consumption over 5 weeks favorably alters HDL cholesterol and apoprotein profiles.
- These changes may contribute to the observed inverse relationship between moderate alcohol intake and cardiovascular mortality.
- Further research is warranted to elucidate the precise mechanisms and long-term implications.
Abstract:
Moderate alcohol consumption is associated with lower cardiovascular mortality. The effect of moderate alcohol intake during 5 weeks on lipoproteins, especially on the high density lipoprotein (HDL) cholesterol total (of which the levels are inversely predictive of coronary heart disease) and apoproteins A, A1 and B, was studied in 7 normal men. HDL cholesterol total appreciated by the heparin manganese precipitation method and phosphotungstate magnesium method increased (p less than 0.01) during alcohol consumption. The composition of HDL was modified by alcohol consumption: increase of the esterified/total cholesterol ratio (p less than 0.05) and phospholipids (p less than 0.05) without significant modification of triglycerides. Low density lipoprotein and very low density lipoprotein did not vary significantly. Apoprotein A1 increased during alcohol consumption (p less than 0.05) with a transitory increase of apoprotein A. There was no significant modification of apoprotein B.