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Concentrations of cefmetazole in plasma and tissue resulting from peri-incisional administration before appendectomy
Abstract:
The levels of cefmetazole in plasma and tissue were determined after injection of a dose of 30 mg/kg into the zone of the wound of each of 15 patients undergoing appendectomy. The mean plasma levels of cefmetazole at the start and end of surgery (8.9 +/- 2.4 and 31.7 +/- 6.4 min after dosage) were 21.1 and 59.0 micrograms/ml, respectively; concentrations of the drug were 14.6 and 4,486.9 micrograms/g in skin, 9,165.0 and 1,756.4 micrograms/g in subcutaneous tissue, and 8,669.6 and 2,022.9 micrograms/g in muscle.
Insights
This study measured cefmetazole levels in appendectomy patients. The antibiotic achieved high concentrations in plasma and surgical tissues, indicating effective wound site delivery.
Area of Science:
- Pharmacology
- Surgical Infection Prophylaxis
Background:
- Cefmetazole is a cephalosporin antibiotic used for surgical prophylaxis.
- Understanding drug distribution at surgical sites is crucial for effective infection control.
Purpose of the Study:
- To determine the plasma and tissue concentrations of cefmetazole after local administration in patients undergoing appendectomy.
- To evaluate the pharmacokinetic profile of cefmetazole in the wound zone.
Main Methods:
- 15 patients undergoing appendectomy received a 30 mg/kg dose of cefmetazole into the wound area.
- Plasma and tissue (skin, subcutaneous tissue, muscle) samples were collected at different time points during surgery.
- Cefmetazole concentrations were quantified using appropriate analytical methods.
Main Results:
- Mean plasma cefmetazole levels increased from 21.1 µg/ml at the start to 59.0 µg/ml at the end of surgery.
- High concentrations were observed in surgical tissues: skin (14.6–4,486.9 µg/g), subcutaneous tissue (9,165.0–1,756.4 µg/g), and muscle (8,669.6–2,022.9 µg/g).
- Concentrations varied significantly between tissue types and over time.
Conclusions:
- Local administration of cefmetazole results in substantial plasma and tissue concentrations at the surgical site.
- These findings support the potential efficacy of cefmetazole for preventing surgical site infections following appendectomy.
- Further research may explore optimal dosing and timing for cefmetazole wound site infiltration.