Testicular effects of some xanthine derivatives in the rat

Testicular toxicity as well as effects on body weight gain and food consumption of four xanthine derivatives were studied in the Sprague-Dawley rat. The influence on toxicity by variation of the substituent at positions 1 and 3 on the xanthine skeleton was tested. The compounds were administered orally once a day for 1 month. The 1-methylated xanthines seemed to be more toxic than the non-methylated compounds.