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A comparative retrospective analysis of data from short- and long-term animal toxicity studies on 40 pharmaceutical
Archives of Toxicology. Supplement. = Archiv Fur Toxikologie. Supplement
|January 1, 1984
Abstract:
A comparative retrospective survey of data from chronic toxicity studies has been carried out on 40 pharmaceutical compounds based on comprehensive information from 19 pharmaceutical companies. The results showed that no new salient toxicological effects were observed in tests of more than 6 months duration excluding carcinogenicity studies. Since no additional information was identified by dosing animals continuously for 12-18 months, the value of prolonging chronic toxicity studies in animals beyond 6 months should be carefully reassessed.