Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

DNA methylation versus gene expression.

A P Bird

    Journal of Embryology and Experimental Morphology
    |November 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    DNA methylation patterns influence gene expression, but this relationship varies between genes. Understanding this variability may require an evolutionary perspective for stable gene expression inheritance.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Transbuccal peptide delivery: stability and in vitro permeation studies on endomorphin-1.

    Journal of controlled release : official journal of the Controlled Release Society·2001
    Same author

    Dosage compensation in birds.

    Current biology : CB·2001
    Same author

    DNA recognition by the methyl-CpG binding domain of MeCP2.

    The Journal of biological chemistry·2000
    Same author

    Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a.

    Proceedings of the National Academy of Sciences of the United States of America·2000
    Same author

    CpG island libraries from human chromosomes 18 and 22: landmarks for novel genes.

    Mammalian genome : official journal of the International Mammalian Genome Society·2000
    Same author

    Methylation-induced repression--belts, braces, and chromatin.

    Cell·1999

    Area of Science:

    • Epigenetics
    • Molecular Biology
    • Genetics

    Background:

    • Vertebrate DNA features high methylation at CpG sites.
    • DNA methylation patterns are heritable through cell division.
    • This suggests a mechanism for stable, clonally inherited gene expression patterns.

    Purpose of the Study:

    • To review evidence linking DNA methylation and gene expression.
    • To explore the variable nature of this relationship.
    • To consider an evolutionary perspective for explaining variability.

    Main Methods:

    • Review of current scientific literature on DNA methylation and gene expression.
    • Analysis of studies investigating the impact of 5-methylcytosine on gene transcription.
    • Comparative analysis of gene expression patterns in relation to methylation status.

    Related Experiment Videos

    Main Results:

    • Evidence suggests DNA methylation influences gene expression patterns.
    • The relationship is not uniform; some genes are repressed by methylation, while others are unaffected.
    • The presence of 5-methylcytosine can repress transcription in certain contexts.

    Conclusions:

    • DNA methylation plays a role in regulating gene expression.
    • The impact of DNA methylation on gene expression is gene-specific and context-dependent.
    • An evolutionary viewpoint may help elucidate the variability in DNA methylation's role in gene expression.