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The requirement for the Fc portion of antibody in antigen-antibody complex-mediated suppression

E L Morgan, C H Tempelis

    Journal of Immunology (Baltimore, Md. : 1950)
    |May 1, 1978
    PubMed

    The role of the Fc portion of antibody in immune complex-induced suppression was studied in vivo and in vitro. BSA pheasant anti-BSA complexes, formed in antigen excess (Ag1Ab1), were found to suppress both responses to BSA and SRBC. When complexes were formed with F(ab')2 fragments of pheasant anti-BSA, no suppression was observed, indicating that the Fc piece was indeed essential for the induction of Ag-Ab complex-mediated suppression.

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