Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The early adaptive evolution of calmodulin.

M L Baba1, M Goodman, J Berger-Cohn

  • 1Department of Anthropology, Wayne State University, Detroit, Michigan.

Molecular Biology and Evolution
|November 1, 1984
PubMed
Summary

Natural selection drives molecular evolution by favoring new functions after gene duplication and conserving existing ones over time. This study reveals varying evolutionary rates across protein families, with calmodulin showing rapid early changes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correlating purity by microdissection with gene expression in gastric cancer tissue.

Scandinavian journal of clinical and laboratory investigation·2007
Same author

Therapeutic strategy for signet ring cell carcinoma of the stomach.

The British journal of surgery·2004
Same author

Structure of the C-terminal RNA-binding domain of hnRNP D0 (AUF1), its interactions with RNA and DNA, and change in backbone dynamics upon complex formation with DNA.

Journal of molecular biology·2001
Same author

Identification of major phosphorylation sites of Epstein-Barr virus nuclear antigen leader protein (EBNA-LP): ability of EBNA-LP to induce latent membrane protein 1 cooperatively with EBNA-2 is regulated by phosphorylation.

Journal of virology·2001
Same author

Herpes simplex virus 1 alpha regulatory protein ICP0 functionally interacts with cellular transcription factor BMAL1.

Proceedings of the National Academy of Sciences of the United States of America·2001
Same author

Interaction of Epstein-Barr virus nuclear antigen leader protein (EBNA-LP) with HS1-associated protein X-1: implication of cytoplasmic function of EBNA-LP.

Journal of virology·2000

Area of Science:

  • Molecular Evolution
  • Genomics
  • Biochemistry

Background:

  • Gene duplication is a key driver of molecular evolution, creating redundant genes that can acquire new functions.
  • The calmodulin protein family, involved in calcium signaling, provides a model for studying evolutionary dynamics.
  • Understanding the interplay between gene duplication and natural selection is crucial for deciphering protein evolution.

Purpose of the Study:

  • To investigate the evolutionary history of the calmodulin protein family.
  • To determine the roles of natural selection in shaping protein evolution after gene duplication.
  • To analyze the relationship between protein function and evolutionary rates.

Main Methods:

  • Phylogenetic tree construction using parsimony analysis on amino acid sequences of 50 calmodulin-family proteins.

Related Experiment Videos

  • Reconstruction of ancestral base substitutions and deletions.
  • Comparative analysis of evolutionary rates across different protein lineages.

    • Main Results:

    • Gene duplication events in the calmodulin family were followed by selection acting as a transforming force, enabling new functions.
    • Later evolutionary stages show selection acting as a conserving force, preserving essential functional sites.
    • Evolutionary rates varied significantly among protein lineages, correlating with the number of molecular interactions; calmodulin and troponin-C evolved slowly, while parvalbumin evolved rapidly.
    • All lineages exhibited a pattern of rapid early evolution followed by slower rates, particularly evident in calmodulin's early history.

    Conclusions:

    • Natural selection acts as both a creative and conserving force in molecular evolution.
    • Functional constraints, particularly the extent of molecular interactions, significantly influence protein evolutionary rates.
    • The calmodulin family's evolutionary trajectory highlights the dynamic interplay between gene duplication, selection, and functional adaptation.