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Related Experiment Videos

Serum protein pattern in normal pregnancy with special reference to acute-phase reactants.

K Haram, K Augensen, S Elsayed

    British Journal of Obstetrics and Gynaecology
    |February 1, 1983
    PubMed
    Summary

    Serum protein levels change during pregnancy, with some proteins like alpha 1-Antitrypsin increasing and others like haptoglobin fluctuating. This study establishes reference ranges for these serum proteins in healthy pregnancies.

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    Area of Science:

    • Clinical Biochemistry
    • Maternal-Fetal Medicine
    • Immunology

    Background:

    • Serum protein concentrations undergo dynamic changes during pregnancy.
    • Understanding these alterations is crucial for monitoring maternal and fetal health.
    • Existing data on specific protein changes throughout gestation is limited.

    Purpose of the Study:

    • To quantify the concentrations of acute-phase protein reactants, total protein, albumin, and globulin fractions during normal pregnancy.
    • To establish reference ranges for serum proteins in healthy pregnant individuals.
    • To describe the longitudinal changes in specific serum proteins throughout pregnancy.

    Main Methods:

    • Serum samples were collected from 27 women throughout their normal pregnancies.

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  • Concentrations of total protein, albumin, globulin fractions, and acute-phase reactants were measured.
  • Data analysis focused on tracking protein levels across different trimesters and gestational periods.

    • Main Results:

    • Alpha 1-Antitrypsin and caeruloplasmin concentrations progressively increased, peaking in the third trimester.
    • Orosomucoid and haptoglobin levels were elevated in the first and third trimesters, with a dip around 24 weeks.
    • C-Reactive protein remained consistently low (<5 mg/l), similar to non-pregnant levels, while alpha 1-, alpha 2-, and beta-Globulin increased towards term. Gamma-Globulin showed minimal change.

    Conclusions:

    • Pregnancy is associated with significant, yet predictable, alterations in serum protein concentrations.
    • The study provides valuable reference ranges for key serum proteins during healthy pregnancy.
    • These findings aid in the interpretation of protein profiles in pregnant women.