Some immunological studies in aplastic anaemia

Peripheral blood studies in 29 patients with aplastic anaemia showed decrease in the mean numbers of total lymphocytes, T and B lymphocytes and monocytes. Quantitation of serum immunoglobulins carried out in 22 patients showed normal results in most cases. Although the significance of these immunological changes in the development of aplastic anaemia is not established they may represent a factor in addition to neutropenia in the pathogenesis of infections in this disease.